-Obesity with BMI > 35 kg/m2-History of oophorectomy-With untreated hydrosalpinx, endometrial polyp or submucous myoma at beginning of treatment-With endocrinological disorders for, e.g., thyroid/adrenal disease-Allergy to DHEA-Treated with insulin for diabetic management. The gene discussed is INS; the disease is Obesity.