ACE2 and diabetes mellitus: It is important to point out that this relationship is supported by a previous study that investigated the pathogenesis of pancreatic lesions and glucose intolerance in SARS patients during the SARS coronavirus (SARS-CoV) global alert in March 2003, which revealed that angiotensin-converting enzyme 2 (ACE2) expression in the exocrine and endocrine tissues of the pancreas suggested that SARS-CoV may damage islets and cause acute insulin-dependent diabetes mellitus [45].