Overexpression of serine protease inhibitor, clade E member 1 (SERPINE1), Toll-like receptor 2 (TLR2), and CC Chemokine ligand 20 (CCL20) were also reported as a significant causative factors in the progression of arteriosclerosis, thrombosis, differentiation of SMCs and perivascular fibrosis [34,35,36]. The gene discussed is TLR2; the disease is arteriosclerosis disorder.