Serum protein electrophoresis should be considered for individuals who present with a vertebral compression fracture of unknown etiology to assess multiple myeloma or monoclonal gammopathy, a 24-hour urinary cortisol/overnight dexamethasone suppression test may be considered if Cushing’s disease is suspected and anti-tissue transglutaminase immunoglobulin A antibody levels may be measured if celiac disease is suspected. Here, TGM2 is linked to celiac disease.