T-regulatory cells (Tregs), responsible for immune homeostasis, suppression of autoreactive lymphocytes and release of different cytokines, such as IL-10 and TGF-β [27], have been detected with increased values in blood samples from pSS patients with EGMs, while a reduction in Treg cells seems to prevent the emergence of EGMs in these patients [28,29]. The gene discussed is IL10; the disease is peeling skin syndrome.