Efforts to identify biomarkers other than calcitonin in MTC have been made, and procalcitonin, chromogranin A, neuron-specific enolase (NSE) and carbohydrate antigen 19-9 (CA 19-9) have been proposed, but this is still an open challenge for clinicians [10]. The gene discussed is CALCA; the disease is medullary thyroid gland carcinoma.