Our recent studies showed that CD4+ T cells specific for the core lipoprotein ApoB (apolipoprotein B), which is involved in LDL, very low-density lipoproteins, and chylomicron, are mostly Tregs in people without cardiovascular disease, but assume mixed and effector phenotypes in those with cardiovascular disease [49,64]. The gene discussed is APOB; the disease is cardiovascular disorder.