Briefly, the CD47 cell surface receptor on tumor cells forms a complex with signal-regulatory protein alpha (SIRPα) on phagocytic cells, resulting in the recruitment of SHP-1 and SHP-2 that prevent the accumulation of myosin IIA in the phagocytic synapse, ultimately inhibiting phagocytosis [16,17,18]. The gene discussed is CD47; the disease is neoplasm.