This leads to peripheral insulin resistance and impairment of pancreatic β-cell insulin secretion, while the adipocytes elevate adipokine secretion, NGF, interleukin 6 (IL-6), IL-1, tumor necrosis factor-α (TNF-α), and monocyte chemoattractant protein-1 (MCP-1). The gene discussed is INS; the disease is Insulin resistance.