Interestingly, it was shown that all five CV biomarkers (including cTnT, proatrial natriuretic peptide, copeptin, proadrenomedullin, and NT-proBNP) had a prognostic significance for mortality risk, that did not interact with renal dysfunction and could be interpreted independently of eGFR [53]. This evidence concerns the gene NPPB and Abnormal renal physiology.