F2 and hyperinsulinemic hypoglycemia, familial, 4: In a multivariate logistic regression model including age, sex, body mass index, ECMO configuration, arterial and venous cannula sizes, minimum prothrombin time, fibrinogen levels and platelet counts, maximum activated partial thromboplastin time, and the number of ECMO days, only factor XIII deficiency was significantly associated with the occurrence of one or more major bleeding events (p = 0.03).