Notably, epigenetic modifications in the central Th2 commitment genes exhibit a predictive ability regarding eczema exacerbation during childhood; hypermethylation of the IL-4R CpG +28269 region in the umbilical cord was associated with the incidence of AD at 12 months and 6–7 years, suggesting putative novel biomarkers in disease onset and progression [51]. Here, IL4R is linked to Alzheimer disease.