In a sub-analysis of the PIONEER-HF trial (comparison of the effect of sacubitril/valsartan vs. enalapril on NT-proBNP in patients stabilized after an AHF episode), a significant reduction of circulating sST2 values as early as 1 week was demonstrated in patients in the sacubitril/valsartan arm compared to patients treated with enalapril. Here, NPPB is linked to hydrops fetalis.