Compared to the 143 study patients (GEIRD dataset), the 842 asthma cases who were assessed in the replication analysis (ECRHS II dataset) had higher BMI (median: 25.1 vs. 24.5, p = 0.024), a lower percentage of subjects with nasal allergies (44.1% vs. 69.2%, p < 0.001), a higher percentage of subjects with eczema/other skin allergies (51.8% vs. 34.3%, p < 0.001), a higher percentage of subjects reporting an itchy rash (23.2% vs. 14.0%, p = 0.013), and lower total IgE (geometric mean: 54.1 vs. 111.5, p = 0.003) (Table 1). Here, IGHE is linked to asthma.