In conclusion, SGLT2-is appear to not significantly interfere with the onset of osteomyelitis, PAD, lower limb fractures, or symmetric polyneuropathy, even though the number of these events proved consistently higher in almost all the investigational groups; otherwise, local ulcers, amputations, and overall infections may be favoured by their employment. The gene discussed is SLC5A2; the disease is osteomyelitis.