Future research should explore the different efficacies of the available biological therapies in this specific phenotype and also investigate the role of anti-IL-4Rα [57,58] and anti-thymic stromal lymphopoietin (TSLP) [59] monoclonal antibodies, with the goal of determining the best approach for patients with severe uncontrolled asthma with the co-presence of severe bronchiectasis. The gene discussed is TSLP; the disease is bronchiectasis.