Multiple metabolic mechanisms have been implicated the physiopathology of diabetic retinopathy, such as the polyol pathway, advanced end products (AGEs) accumulation, the protein kinase C (PKC) pathway, inflammation, vascular endothelial growth factor (VEGF) expression, the hexosamine pathway, renin-angiotensin upregulation and oxidative stress [4,6]. This evidence concerns the gene VEGFA and diabetic retinopathy.