HAVCR1 and chronic kidney disease: When summarising one of the most reliable studies on KIM-1 in children with CKD, both plasma and urinary KIM-1 were associated with the progression of CKD; however, urinary KIM-1, rather than plasma KIM-1, is statistically a better predictor of CKD progression as it improved three independent clinical risk prediction metrics: c-statistics, integrated discrimination improvement and continuous net reclassification improvement [39,51].