Additionally, it has been shown that tissue expressions of certain biomarkers, such as Cytokeratin [21], Podoplanin, Vimentin, Programmed Cell Death Ligand-1, or Epidermal Growth Factor Receptor, are significantly associated with the risk of lymph node metastasis [23,24,25]. The gene discussed is PDPN; the disease is metastatic malignant neoplasm in the lymph nodes.