Glitazones activate nuclear peroxisome proliferator-activated receptor ƴ receptors and exert their action through three known mechanisms: (1) improvement in insulin resistance with little or no tendency to produce hypoglycemia; (2) increase in glucose uptake by skeletal muscle through the regulation of adipocyte cytokines responsible for insulin sensitization; and (3) decrease in hepatic glucose production. This evidence concerns the gene INS and Hypoglycemia.