Ultimately, while there are no specific guideline-based therapies for determining which intrathecal agent to use for which primary tumor, data suggest a benefit of (1) MTX in LM due to solid neoplasms, (2) trastuzumab for LM due to HER2-positive malignancies, and (3) pemetrexed for LM secondary to lung adenocarcinoma [68]. The gene discussed is ERBB2; the disease is neoplasm.