The same group then identified three immune profiles of ccRCC: immune-regulated (CD8 PD-1+TIM-3+LAG-3+ TILs and T regs), immune-activated (CD8 PD-1+ TIM-3+ TILs), and immune-silent (enriched with TILs similar to those in the adjacent non-malignant tissue). This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.