A comparison of the consistently anti-U1-RNP-negative samples (n = 59) with the anti-RNP70-positive (n = 21) SLE samples showed that the anti-RNP70-positive SLE subgroup had a lower age (p = 0.001), a shorter disease duration (p < 0.0001) and a lower SDI (p = 0.008), while the fulfillment of the hematologic disorder criterion (p = 0.007) and the presence of RP (p = 0.003) were more common compared to the anti-U1-RNP-negative group. This evidence concerns the gene SNRNP70 and systemic lupus erythematosus.