At the time of sampling, there was a non-significant trend of higher disease activity, as assessed using the clinical SLE disease activity index 2000 (cSLEDAI-2K; p = 0.05), whereas acquired organ damage, as assessed by the Systemic Lupus International Collaborating Clinics/ACR damage index (SDI), was lower (p = 0.006) in the anti-U1-RNP-positive individuals with SLE (Table 1). This evidence concerns the gene SNRNP70 and systemic lupus erythematosus.