It has been postulated that cancer cells with NRF2 activation may develop “NRF2 addiction”, whereby NRF2 acts as a facultative cancer driver, able to confer malignant phenotypes but only if certain prerequisites of active oncogenic signalling are present in the tumour cell; these prerequisites are not fully unveiled, as they seem to be cell-type specific [17]. Here, NFE2L2 is linked to cancer.