INS and obesity due to melanocortin 4 receptor deficiency: To investigate which of the 15 tested biochemical parameters (FPG, 2h-PG, HbA1c, insulin, C-peptide, HOMA-IR, total cholesterol, HDL-C, LDL-C, TG, hsCRP, VEGF, IL-10, adiponectin and leptin) showed the highest discriminant value in identifying the risk of obesity, we used the ROC (Relative Operating Characteristic) curve analysis.