The analysis of ROC curves for obesity showed that in all our patients (study and control), out of 15 tested parameters (FPG, 2h-PG, HbA1c, insulin, C-peptide, HOMA-IR, total cholesterol, HDL-C, LDL-C, TG, hsCRP, VEGF, IL-10, adiponectin, leptin), the highest discriminating powers for obesity were found for insulin, C-peptide, HOMA-IR and leptin. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.