Actin-related protein 2/3 complex subunit 1B (ARPC1B) can activate the NF-κB and STAT3 signaling pathways by inhibiting the TRIM21-mediated degradation of IFI16 and HuR, which promotes MES phenotype maintenance and radiotherapy resistance of GBM [130]. Here, ELAVL1 is linked to glioblastoma.