HIF1A and glioblastoma: Apigenin can inhibit the p65/HIF-1α-mediated expression of glucose transporter 3 (GLUT3) and pyruvate kinase isozyme-type M2 (PKM2) and wakens the stem cell and DNA damage repair of GBM cells, thereby increasing the radiosensitivity of GBM [139] (Table 1).