For instance, RNA-binding protein TAR DNA-binding protein 43 (TDP43) and transcription factor activator protein 1 (AP-1) can upregulate circADAMTS6, and circADAMTS6 is specifically upregulated in the hypoxic microenvironment of GBM, and can also accelerate GBM progression via the ANXA2/NF-κB pathway [53]. This evidence concerns the gene NFKB1 and glioblastoma.