The WD repeat-containing protein 5 (WDR5)/mixed lineage leukemia (MLL) complex can bind to the promoter of E3-ligases FBXO32, mediating active histone modifications, including H3K4me3 and H3K9ac, leading to the upregulation of FBXO32, and further activated NF-κB/O(6)-methylguanine-DNA methyltransferase (MGMT) signaling via the ubiquitin-dependent degradation of IκBα, which further downregulates the expression of brain acid soluble protein 1 (BASP1) to promote the resistance of GBM cells to TMZ [119]. Here, NFKB1 is linked to glioblastoma.