For example, the expression of RNA-binding protein ADAR3 can activate NF-κB signaling by altering the expression or activity of one of the many upstream factors that regulate NF-κB activity to increase the GBM cell resistance for TMZ, and NF-κB signaling also promotes the expression of ADAR3 [118]. The gene discussed is NFKB1; the disease is glioblastoma.