KEAP1 and glioblastoma: For instance, cynaropicrin (CYN), a natural compound that was isolated from an edible plant (artichoke), can induce ERK dephosphorylation accompanied by a reduction of p65 to promote GBM cell apoptosis via inhibiting the p62/Keap1/Nrf2 pathway; additionally, CYN also increases the cytotoxicity of TMZ to GBM [140].