Esophageal carcinoma-related gene 4 (ECRG4) can inhibit AKT/GSK3β/β-catenin signaling to reduce tumor cell migration and invasion [79], however, ubiquitin protein ligase E3 module N-recognition 5 (UBR5) can bind to and degrade ECRG4, thereby promoting the phosphorylation and nucleation of p65, and inducing the migration and invasion of GBM [80]. This evidence concerns the gene ECRG4 and carcinoma of esophagus.