These results suggest that CKD promotes the development of biomarker-assessed myocardial fibrosis and LVDD in hypertensive patients with HFpEF, and that changes in collagen type I metabolism as measured by the biomarkers PICP and CITP:MMP-1 ratio worsen with the transition to HFpEF in hypertensive patients [15]. The gene discussed is MMP1; the disease is Myocardial fibrosis.