As described above, several autoantibodies against IgE antibody and/or FcεRI (IgG antibody) and self-molecules, such as IL-24, dsDNA and TPO (IgE antibody), contribute to the basophils and mast cells activation, resulting in the release of chemical mediators, such as histamine, followed by the development of urticaria (autoimmune CSU). The gene discussed is IGHE; the disease is urticaria.