Since basophils are a major source of IL-4, as well as in peripheral blood mononuclear cells, basophils are considered to play critical roles in type 2 inflammations and IgE antibody-associated allergic disorders (type I allergy), such as urticaria, asthma, pollen allergy, food allergy, anaphylactic shock and atopic dermatitis (AD) [21,22]. Here, IGHE is linked to urticaria.