in vitro:- Blocking of cell proliferation and induction of apoptosis of myeloma cell lines;- Cell death of KMS-11 cells grown in the presence of HS-5 bone marrow-derived stromal cells- Inhibition of tumor growth in a KMS-11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin D2 levels;. This evidence concerns the gene STAT3 and plasma cell myeloma.