BLK and mantle cell lymphoma: Other NOTCH1 targets in MCL are genes involved in cytokine and interleukin signaling, such as IL6R, IL10RA, IL21R, and the regulation of B cell receptor activation, including Src-family kinases (BLK, FYN, FGR, and LYN), adaptor proteins (PIK3AP, BLNK, NEDD9, and SH2B2), BCR signaling modulators (CD21 and CD300A), and members of the Fc-receptor-like family (FCRL3, FCRL4, and FCRL5) [38].