In T-ALL, NOTCH1-dependent MYC activation occurs through an interaction between the transcription factor RBPJ and an enhancer on the 3′ side of MYC (termed T-NDME), while in MCL, it takes place at the 5′ side’s enhancers, E1 and E2 [18,38]. The gene discussed is MYC; the disease is acute lymphoblastic leukemia.