Thus, we addressed that knowledge gap by administering the potent, orally bio-available ATX inhibitor PF-8380 (IC50 1.9 nM) by gavage in a mouse model of PDD induced by oral infection with P. gingivalis (strain FDC 381) and have found approximately 40% reduction in alveolar bone loss (study ongoing), so it appears that ATX does play a significant role in the pathogenesis of PDD. This evidence concerns the gene ENPP2 and infection.