Recently, a study undertook the investigation of neurolipid (endocannabinoid), LPA, and S1P signaling and specific lipid species in a mouse model of Alzheimer’s disease (AD) using MALDI-MSI for lipid localization and quantitation and [35S]GTPγS autoradiography to locate the cannabinoid CB1, LPA1, and S1P1 receptor subtypes [107]. This evidence concerns the gene CNR1 and early-onset autosomal dominant Alzheimer disease.