However, in most squamous carcinoma cells, TGF-β suppresses cell-cycle proliferation via G1 arrest, including the inhibition of MYC and cyclin-dependent kinase (CDK) 4 (CDK4), and repression of cyclin activities and induction of the CDK inhibitors p21 (aka CIP1) and p15 (aka INK4B) [34]. Here, CDKN2B is linked to squamous cell carcinoma.