Culture of a series of supernatants from human tumor cell lines with healthy neutrophils from cancer patients showed that CXCR1 and CXCR2 agonists are the primary regulators of tumor-induced NETs production, and blocking CXCR1 and CXCR2 with corresponding inhibitors completely inhibits supernatant-induced NETs production. The gene discussed is CXCR2; the disease is neoplasm.