In patients with sickle cell disease (SCD), intracellular polymerization of mutated hemoglobin can lead to the development sterile inflammation, in vivo microscopic observations of SCD mice and invitro studies of the blood of SCD patients have shown that the sterile inflammatory environment promotes the activation of neutrophil-gasdermin D (GSDMD), which triggers the release of NETs, thus resulting the development of acute lung and neutrophil-platelet aggregation [45]. This evidence concerns the gene GSDMD and sickle cell disease.