On the one hand, myeloid-derived suppressor cells (MDSCs) can produce NETs under the stimulation of IL-8 [16], and at the same time, in the tumor microenvironment, MDSCs can produce chemokines such as CXC chemokine receptor 1(CXCR1) and CXCR2 agonists to promote the production of NETs [17]. Here, CXCR2 is linked to neoplasm.