CXCL8 and cancer: In addition, studies in pancreatic cancer have found that the production of extracellular DNA and CXCL8 on the surface of cancer cells is increased, and the use of DNase I can degrade extracellular DNA, while the proportion of CXCL8 is down-regulated, which ultimately inhibits the metastasis of pancreatic cancer cells [70], and in this process, the transmembrane protein CCDC25 acts as the NET-DNA receptor of pancreatic cancer cells to receive signals and enhance tumor cell mobility through intracellular pathways such as ILK-β-pavin [71].