MAL and myalgic encephalomeyelitis/chronic fatigue syndrome: Despite an overlap of the functional response in males with ME/CFS to female HCs—for example, derangement of the IL-12 pathway—the genes most affected in each group were different, with female HCs having significant alterations in multiple DEGs related to lymphocyte differentiation, signaling, and fate, including MAL and SLC16A10 [12].