Chronic pancreatitis is accompanied with the downregulation of the tumor-suppressing genes, such as p16, TP53, and SMAD4 (mothers against decapentaplegic homolog), respectively, along with the upregulation of the oncogenic KRAS (Kirsten rat sarcoma virus), TNF-α (tumor necrosis factor alpha), and NF-kB (nuclear factor kappa B) genes [5]. The gene discussed is TNF; the disease is neoplasm.