NNK is metabolized by cytochrome P450 enzymes, cyclooxygenases and lipoxygenases and created metabolites after binding to DNA form adducts that are able to form point mutations in numerous genes, including suppressors and protooncogenes e.g., in the KRAS gene, which is considered as one of the most commonly mutated in pancreatic cancer [16]. Here, KRAS is linked to familial pancreatic carcinoma.