GWAS (genome-wide association studies) have revealed that mutations in genes connected with embryonic development and the regulation of pancreas-specific genes such as Nr5a3, HNF1A (hepatocyte nuclear factor 1), and PDX1 (pancreatic and duodenal homeobox 1) are associated with the development of pancreatic cancer. The gene discussed is PDX1; the disease is familial pancreatic carcinoma.