Conversely, GLI1, a vital player in Hedgehog signaling, enhances PI3K/AKT signaling in a Foxm1-dependent manner to increase CRC metastasis [42], while ZNF692 promotes cell proliferation and invasion by altering the expression of proteins involved in cell cycle regulation and angiogenesis, including cyclin D1, CDK2, and p27Kip1, via the PI3K/AKT pathway [43]. The gene discussed is AKT1; the disease is colorectal carcinoma.