When recruited by lncRNA FAM83C-AS1, ZRANB1 de-ubiquitinates and stabilizes histone methyltransferase EZH2 to downregulate the expression of the metastasis suppressor SEMA3F and increase CRC cell stemness, proliferative, and metastatic capabilities [183]. This evidence concerns the gene PRDM9 and colorectal carcinoma.