STAT3 and cancer: According to the KEGG, the strongly associated pathways with MET/STAT3/AKT are the PI3K-AKT signaling pathway, Epstein–Barr virus infection, cell cycle, human papillomavirus infection, focal adhesion, EGFR tyrosine kinase inhibitor resistance, chronic myeloid leukemia, JAK-STAT signaling pathway, thyroid hormone signaling pathway, PD-L1 expression and PD1 checkpoint pathway in cancer, Wnt signaling pathway, VEGF signaling pathway, and platinum drug resistance pathway (Figure 7B).