In S. mansoni infections, Vanella et al. [34] reported that the disruption of IL-33/ST2 signalling does not alter granuloma size or fibrosis and only hampers the expression of Th2 cytokines when blocked, along with IL-25 and thymic stromal lymphopoietin (TSLP) signalling. The gene discussed is IL33; the disease is Granuloma.