Based on the significant involvement of dysregulation of redox homeostasis in cardiac disorders, we have proposed modifying the effect of polymorphisms in catalytic and regulatory antioxidant proteins (SOD2 rs4880, GPX1 rs1050450, GPX3 rs8177412, and Nrf2 rs6721961) in individual susceptibility towards the development of cardiac manifestations of long COVID-19 even after mild to moderate forms of the disease. The gene discussed is GPX1; the disease is COVID-19.