PRKDC and cancer: Actually, most of the disease related to aberrations in DSBs repair protein kinases are marked by growth and developmental problems, such as cancer (abnormal cell proliferation, see details above), Ataxia telangiectasia (with immune and neuron dysfunctions, and radiosensitivity and cancer predisposition features; associated with ATM, PRKDC, CHK1, or CHK2 mutations) [48,49] and Seckel syndrome (growth retardation; associated with ATR mutations) [50].