SQSTM1 and neoplasm: Moreover, considering that SQSTM1/p62 associates with caspase-8 and the subsequent apoptotic pathway [41], PCBP1 downregulation or depletion would be a relevant strategy for tumor cell survival via downregulation of SQSTM1/p62 and caspase-8, suggesting the concept that autophagy inhibition could be an efficient strategy to activate the apoptotic cell death mechanism in colorectal tumor cells [40].