Despite the link of the AKT and Wnt pathways to autophagy in RAS-mutated CRC cells not being well defined, a pharmacological study demonstrated that CK1α is involved in regulation of autophagy, Wnt/β-catenin and AKT pathways in rat sarcoma (RAS)-mutant CRC cell lines. The gene discussed is CSNK1A1; the disease is colorectal carcinoma.