This result can be reported at the genetic level, since CRC cells treated with escin activated autophagy and overexpressed SQSTM1/p62 played an important protective role against escin-induced apoptosis and DNA damage, as SQSTM1/p62 suppresses the ataxia-telangiectasia mutated/phosphorylated histone family member X pathway [44]. This evidence concerns the gene SQSTM1 and colorectal carcinoma.