Another interesting paper showed that apoptotic cell death induced by N1, N11-diethylnorspermine (DENSpm) is boosted when autophagy is inhibited by 3-mase9pethyladenine (3-MA), an autophagy inhibitor, or beclin-1 siRNA through polyamine depletion or polyamine catabolic activation in colon cancer cells, regardless p53 mutation status. Here, BECN1 is linked to malignant colon neoplasm.