MAP1LC3A and colorectal carcinoma: On the other hand, literature has reported that SQSTM1/p62 expression in CRC cells was suppressed by the β-catenin/transcription factor (TCF)4 complex, which blocked phagocytic ingestion, but under stress conditions induced by nutrient depletion, SQSTM1/p62 was markedly raised, as β-catenin was immediately degraded by LC3 binding to the LC3-interacting region (LIR) of β-catenin [39].