ATG12 and colorectal carcinoma: Consistent with this notion, miR-483 promotes the development of CRC by inhibiting the expression level of etoposide-induced 2.4 (EI24), an autophagy associated transmembrane protein [83], and the knockdown of homeobox transcript antisense intergenic RNA (HOTAIR), a well-known lncRNA, stimulates cell apoptosis and suppresses cell autophagy by upregulating microRNA-93 and downregulating autophagy-related 12 (ATG12) in CRC [84].