Recently, Chen et al. showed that silencing circular RNA ubiquitin-associated protein 2 (circUBAP2) decreased the formation of total autophagosomes and autolysosomes in CRC cells, and when circUBAP2 is knocked down, a decrement of LC3B-II expression, a downregulation of LC3B-I/II conversion and the degradation of autophagy-related protein 6 (beclin1), autophagy-related protein 7 (ATG7) and forkhead box O1 (FOXO1) proteins were observed. The gene discussed is FOXO1; the disease is colorectal carcinoma.