The authors demonstrated that SQSTM1/p62 binds the vitamin D receptor (VDR) and may target the nuclear factor-erythroid-2-related factor 2 (NRF2)-quinone oxidoreductase-1 (NQO1) axis via VDR in human CRC cells, promoting CRC cell proliferation and invasion in vivo. The gene discussed is NFE2L2; the disease is colorectal carcinoma.