BECN1 and malignant colon neoplasm: The authors demonstrated that miR-30d inhibited autophagy and promoted apoptosis of colon cancer cells by directly targeting ATG5, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB) and beclin 1 (BECN1); the inhibition of proliferation was due to negative regulation of cell autophagy and promotion of cell death [77].