Furthermore, through its D2R, DA not only has an effect on decreasing angiogenesis [86,87], but it also inhibits tumor endothelial cell proliferation through the inactivation of VEGF-induced mitogen-activated protein kinase (MAPK) and focal adhesion kinase (FAK) phosphorylation (Figure 2) [78,88]. The gene discussed is VEGFA; the disease is neoplasm.