In another study, soluble intercellular adhesion molecule 1 (sICAM-1), macrophage migration inhibitor factor (MIF), IL-1b., and soluble urokinase plasminogen activator receptor (su-PAR) were all increased in patients with AE-IPF and MIF, and IL-1b, in particular, was independently associated with 3-month mortality [65]. This evidence concerns the gene ICAM1 and idiopathic pulmonary fibrosis.