The M89b treatment on the Panc11074 PDX-bearing mice decreased the expression of the proliferation-inducing genes, including the tumor proto-oncogene Rac GTPase-activating protein 1 (RacGap1; p < 0.05), the cell nuclear antigen (PCNA; p < 0.01), and the matrix metalloproteinase 13 (MMP13; p < 0.05) in the tumor tissue (Figure 2A–C). The gene discussed is MMP13; the disease is neoplasm.