SCN10A and chronic obstructive pulmonary disease: Genome-wide association studies reported that variants in the SCN10A gene (coding for NaV1.8) are associated with cardiac arrhythmias such as atrial fibrillation, sudden cardiac death [16,17], impaired conduction in the form of alterations in the PQ and QRS intervals, heart rate and increased arrhythmogenic risk [16], and with J-wave syndromes, specifically Brugada syndrome (BrS) and early repolarization syndrome (ERS) [18].