There is also a number of ORF genes with different expression in ≥ five cancers (mentioned here, ‘a pan-cancer group’) (Figure 2): preferentially down-regulated genes (C11orf96, C5orf38 and C8orf88); preferentially up-regulated genes (C19orf48, C1orf210, C4orf48 and C6orf132); mixed type of gene expression (C1orf162, C2orf54, C2orf74 and C14orf132). Here, NICOL1 is linked to cancer.