In this study, two highly specific gene expression signatures (C14orf119 and C5orf46) and (C16orf78, C16orf86, C16orf96, C19orf18, C20orf144, C22orf42 and C3orf62) were found for PAAD that are associated with the overall survival of patients and disease-free survival, respectively. Here, C5orf46 is linked to pancreatic adenocarcinoma.