Impaired interaction of C19orf44 protein with the testis-specific multifunctional enzyme GAPDHS (glyceraldehyde-3-phosphate dehydrogenase, 44 PPIs in the BioGRID database, ≥2 evidence) may be associated with modulation of spermatogenesis and male fertility [41] or metabolic reprogramming in cancers via GAPDH [42]. The gene discussed is GAPDH; the disease is cancer.