In the present study, the role of EPB41L3 was investigated by comparing mRNA and protein expression between lung fibroblasts derived from patients with IPF and those of controls and by regulating the EMT of an epithelial cell line (A549) and FMT of a fibroblast cell line (MRC5) by overexpressing and silencing EPB41L3. The gene discussed is EPB41L3; the disease is idiopathic pulmonary fibrosis.