For instance, high serum IL-6 and IL-1 as the hyper-inflammation markers [117,118] plus elevated Q6MeG and normal HLA-DR (a marker of sepsis immune exhaustion [114,115]) with negative blood culture (a biomarker of good control of the source of infection) might be the indicators for properly using of MGMT inhibitors in sepsis. The gene discussed is IL6; the disease is infection.