TNF and bacterial infectious disease with sepsis: With antibiotic use, mgmt null mice demonstrated less severe sepsis than sepsis in littermate control, as indicated by survival analysis, kidney injury (serum creatinine and renal histology score), liver damage (serum alanine transaminase and liver histological score), spleen apoptosis, cell-free DNA, endotoxemia, bacteremia, and serum cytokines (TNF-α, IL-6, and IL-10) (Figure 5A–G and Figure 6A–G).