Because of the impacts of mgmt-manipulated macrophages (Figure 3 and Figure 4) and the importance of antibiotics in sepsis [61], further exploration in mgmt null mice (mgmtfl/fl; LysM-Crecre/-) and mgmt littermate control (mgmtfl/fl; LysM-Cre-/-) using CLP surgery with and without antibiotics were performed. The gene discussed is MGMT; the disease is Sepsis.