MGMT and cancer: Because (i) previous studies of DNA methylation in sepsis are mentioned [41,87,88,89], (ii) the possibility that increased O6MeG (due to the loss of mgmt for DNA repair) might enhance cell injury [85], (iii) the availability of mgmt inhibitor for anti-cancer [90] that possibly be helpful for sepsis [91], and (iv) epigenetic changes and in vitro tests of mgmt inhibitors in LPS-activated macrophages [45,92], further tests on mice with the depletion of MGMT enzyme only in the myeloid cells are interesting.