MC4R and Anorexia: Although the MC3R has also been suggested as a potential target for anorexia, with an MC3R agonist ligand that has been claimed to result in an increased food intake in rodents [23], the dual nanomolar MC3R agonist/MC4R antagonist pharmacology of the Ac-Arg-Arg-DPhe(pI)-Tic-NH2 tetrapeptide [24] utilized complicates the interpretation of the receptors responsible for the observed increased feeding response as it is well recognized that MC4R antagonist ligands increase food intake responses [25].