Because of (i) previous reports of DNA methylation (dnmt) and histone modification (ezh) on sepsis [43,73,79,80], (ii) possible enhanced cell injury from the presence of O6MeG due to the loss of mgmt for DNA repair [72], (iii) the availability of the MGMT inhibitor for oncotherapy [81] and its possible use in some chemotherapeutic strategies as a sepsis immune modulator [82], and (iv) epigenetic changes in LPS-activated macrophages and the reversal of LPS tolerance by the mgmt inhibitors [47,83], further tests on mgmt will be interesting. The gene discussed is MGMT; the disease is Sepsis.