MGMT and cancer: Because (i) sepsis and LPS induce DNA methylation, including Q6MeG [43], (ii) MGMT reduces O6MeG during the DNA repair, and (iii) an MGMT inhibitor (Lomeguatrib) enhances the death of cancer cells (DNA repair interference) [45] that might be beneficial in sepsis [46], the blockage of MGMT in macrophages might reduce macrophage activity and attenuate sepsis-related hyper-inflammation.